Dan Shamble, Zombie P.I., faces his most fowl case yet, when a flock of murderous feral chickens terrorizes the Unnatural Quarter. Also in the caseload, Dan deals with a sinister spokesman for Monster Chow Industries, a serial-killer demon from the Fifth Pit of Hell, an evil gang dealing in black-market blood supplies led by the nefarious Ma Hemoglobin, a ghost fighting a hostile takeover in a chain of blood bars, a spreading contamination that drives vampires berserk, and a cute little vampire girl who may, or may not, be his daughter.

With his ghost girlfriend Sheyenne, his bleeding-heart human lawyer partner Robin, and his Best Human Friend Officer Toby McGoohan, Dan Shamble is ready to solve the case. The feathers will fly as he goes face-to-beak with the evil peckers.